Treatment of chronic constipation: Prescription medications and surgical therapies. Gastrointestinal injury associated with NSAID use: A case study and review of risk factors and preventative strategies. Avoid using anticholinergic medication to treat overactive bladder in women older than 70 years.Opioid-induced constipation: A review of health-related quality of life, patient burden, practical clinical considerations, and the impact of peripherally acting μ-opioid receptor antagonists. You can learn more about how we ensure our content is accurate and current by reading our editorial policy. We link primary sources - including studies, scientific references, and statistics - within each article and also list them in the resources section at the bottom of our articles. Medical News Today has strict sourcing guidelines and draws only from peer-reviewed studies, academic research institutions, and medical journals and associations. However, if these do not work, they will prescribe medications, which include: In people with opioid-induced constipation, doctors will likely suggest lifestyle changes and OTC medications. bile acid-modifying agents, such as elobixibat - currently only approved in Japan and Thailand.secretagogues, such as linaclotide ( Linzess).serotonin agonists, such as prucalopride ( Motegrity).Learn more about laxatives for constipation here.įor people with chronic constipation, a doctor may recommend a person take one of the following prescription drugs: They may also ask a person to take osmotic laxatives daily. laxatives here.ĭ octors typically give stimulant laxatives for opioid-induced constipation. Gas, bloating, and cramping worsen constipation if not taken with enough fluids ![]() Psyllium (Metamucil), methylcellulose (Citrucel)Ībsorbs liquid in the intestines to form bulkier stools that are softer and easier to pass Makes stool softer by allowing fat and water to soften stool Polyethylene glycol or PEG ( MiraLAX), lactulose, milk of magnesiaĭraws water into the intestines to allow stool to pass easierīloating, cramping, gas, nausea, increased thirst, diarrhea Osmotic laxatives (liquid, powder, suppository, saline) Stimulates intestinal muscles to help stool move more quicklyīelching, diarrhea, cramping, nausea, changes in urine color Aside from causing darker-than-usual stools, it may also cause constipation. IronĪ person can take iron on its own or with multivitamins. Citalopram and fluoxetine are examples of SSRIs. One of the most common side effects of TCAs includes constipation.Īnother class of antidepressants, serotonin specific reuptake inhibitors (SSRIs), can also cause constipation. Some examples of TCAs include amitriptyline (Elavil) and desipramine (Norpramin). These medications increase a person’s norepinephrine and serotonin levels by blocking acetylcholine. Tricyclic antidepressants (TCAs) are a class of medications doctors prescribe to treat depression. Antihistamines or allergy medications: These include medications, such as cetirizine (Zyrtec) and diphenhydramine ( Benadryl).Medicines for bladder incontinence: Doctors commonly prescribe oxybutynin (Ditropan) and tolterodine (Detrol) for incontinence issues. ![]() Certain nausea medications: These include ondansetron, which doctors usually prescribe after chemotherapy or surgery.Calcium-channel blockers: These include medications include amlodipine (Norvasc) and diltiazem (Cardizem, Tiazac).These drugs prevent activity by the neurotransmitter acetylcholine, which enables muscles to move, and may cause constipation. AnticholinergicsĪnticholinergics are a large drug class present in many over-the-counter (OTC) and prescription medications. Moreover, using them in higher doses may also lead to constipation. Over-the-counter pain relievers, such as nonsteroidal anti-inflammatory drugs (NSAIDs) may cause gut problems.Ĭ onstipation is also a side effect of NSAIDs, such as ibuprofen (Advil) and naproxen (Aleve). They may also suppress the secretion of water and electrolytes in the intestines and increase fluid absorption by the intestines, removing moisture from the stool. ![]() Opioids affect certain receptors in the gut wall, which slow down the peristaltic movement of the muscles that move food along the tract. Doctors typically prescribe laxatives along with opioids to prevent constipation. Several medications may contribute to constipation: Opioids or pain medicationsīetween 40–60% of people without cancer who take opioids get opioid-induced constipation. Anything that disrupts typical bowel function can cause constipation.
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